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The C-terminal truncated Ex4a(+)WT1 isoform contained the N-terminal transcriptional regulatory area but lacked the zinc finger DNA-binding area, and so the truncated Ex4a(+)WT1 isoform retained the chance to connect with the transcriptional co-activators but lost the ability to bind to promoter of downstream targets. Former research have demonstrated which the N-terminal domainPLOS 1 | DOI:ten.13
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